Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
نویسندگان
چکیده
منابع مشابه
Native and denatured egg white protein IgE tests discriminate hen's egg allergic from egg-tolerant children.
BACKGROUND Accurate diagnosis of egg allergy by IgE testing is challenged by a large number of atopic subjects sensitized, but clinically tolerant to eggs. In addition, discrimination between allergy to raw only, or raw and cooked egg allergy is important. In this study, we investigate the diagnostic performance of IgE tests to native and denatured egg proteins. METHODS According to food chal...
متن کاملThe Equilibria between Native and Denatured Hemoglobin in Salicylate Solutions and the Theoretical Consequences of the Equilibrium between Native and Denatured Protein
The denaturation of hemoglobin by salicylate in neutral solution is completely reversible. There is a mobile equilibrium between native and denatured hemoglobin in neutral salicylate solution. The higher the salicylate concentration the greater is the percentage denaturation. When there is a mobile equilibrium between the native and denatured forms of a protein, denaturation is caused by the ad...
متن کاملThe Equilibrium between Active Native Trypsin and Inactive Denatured Trypsin
There is a mobile equilibrium between the native and denatured forms of trypsin which depends on the concentrations of acid, alkali, and alcohol and on the temperature. The heat of denaturation in 0.01 N hydrochloric acid calculated from the effect of temperature on the equilibrium constant is -67,600 calories per mole.
متن کاملDevelopment of a four-body statistical pseudo-potential to discriminate native from non-native protein conformations
MOTIVATION Most scoring functions used in protein fold recognition employ two-body (pseudo) potential energies. The use of higher-order terms may improve the performance of current algorithms. METHODS Proteins are represented by the side chain centroids of amino acids. Delaunay tessellation of this representation defines all sets of nearest neighbor quadruplets of amino acids. Four-body conta...
متن کاملPresentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis.
Bone marrow (BM)-derived dendritic cells (DC) are potent stimulators of naive CD4+ T cell activation. Because DC are efficient at Ag processing and could potentially present self Ags, we investigated the role of DC in the presentation of an encephalitogenic peptide from myelin basic protein (Ac1-11) in the induction of experimental autoimmune encephalomyelitis (EAE). To determine if DC could pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Medicine
سال: 2007
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm1488